Cosmetic Grade D-Serine(CAS 312-84-5)
Product Name: D-Serine
Abbreviation: D-Ser
Chemical Name: D-2-Amino-3-Hydroxypropanoic Acid
CAS No.: 312-84-5
Grade: Cosmetic Grade (Skin Care Special)
Purity: ≥99.0%
Appearance: White Crystalline Powder, Odorless, Sweet Taste
Molecular Weight: 105.09
Molecular Formula: C₃H₇NO₃
MOQ (Minimum Order Quantity): 1KG
Solubility: Easily soluble in water, slightly soluble in ethanol, insoluble in organic solvents, dissolves rapidly with clear, transparent and impurity-free aqueous solution
Specific Rotation: -14.0° ~ -16.0°
pH Value (1% Aqueous Solution): 5.5 - 7.0
Key Characteristics: Chiral non-essential amino acid, excellent anti-glycation activity, high-efficiency moisturizing, strengthen skin barrier, delay collagen aging, mild and non-irritating, stable formula performance, strong compatibility
Storage Condition: Sealed, dry, cool and dark ventilated environment, avoid high temperature, humid air and direct sunlight, prevent moisture absorption, agglomeration and efficacy attenuation
Shelf Life: 24 Months
Application: Widely used in anti-glycation brightening products, barrier repair skin care series, anti-aging firming lotion and cream, high moisturizing daily skin care and mild functional cosmetics
D-Serine, Cosmetic Grade D-Serine, Anti-Glycation Skin Care Ingredient, Skin Barrier Repair Amino Acid, High Moisturizing Conditioner, Anti-Aging Cosmetic Raw Material, Mild Skin Additive
Cosmetic Grade D-Serine(CAS 312-84-5)
Cosmetic-grade D-Serine is a high-purity chiral amino acid refined by advanced biological synthesis and purification technology, which is a targeted anti-glycation functional raw material exclusive to high-end skin care. Different from conventional L-series amino acids, D-Serine has unique stereoscopic molecular activity, which can precisely inhibit the skin glycation reaction, block the production of AGEs glycation toxins, and fundamentally improve skin yellowing, dullness and relaxation caused by glycosylation aging.
It has super hydrophilic moisturizing performance, can lock basal skin moisture for a long time, relieve dryness and tightness, and maintain skin long-lasting hydration and elasticity. Meanwhile, D-Serine participates in the synthesis of skin ceramides and intercellular lipids, effectively repairing damaged skin barriers, improving skin fragility and sensitivity, and enhancing skin self-tolerance.
With ultra-mild skin-friendly properties, stable acid-base activity, no irritation and no burden on sensitive skin, it can be perfectly compounded with anti-oxidation, anti-aging and brightening ingredients to achieve multi-dimensional skin care effects of anti-glycation, moisturizing and repair. It is a core high-quality raw material for improving sugar-aged skin and daily barrier maintenance.



Key Benefits
• Targeted Anti-Glycation & Anti-Sugar Aging: Precisely inhibit skin glycation reaction, block AGEs generation and deposition, improve skin yellowish, dull and turbid complexion caused by sugar aging, and restore clear skin tone.
• Deep Hydration & Long-Lasting Moisturizing: Super hydrophilic molecular structure, quickly replenish skin basal moisture, form a water-locking protective film, relieve dry tightness and peeling, and keep skin hydrated all day long.
• Repair Barrier & Stabilize Sensitive Skin: Promote the synthesis of skin ceramide and intercellular lipids, repair damaged barrier, reduce redness and sensitivity, and enhance skin defense capability.
• Delay Collagen Aging & Firm Skin: Protect collagen from glycation damage, prevent collagen brittle aging and breakage, improve facial sagging and fine lines, and maintain skin firmness and elasticity.
• Ultra-Mild & Zero Irritation: High-purity refined amino acid ingredient, skin-friendly pH value, low sensitization and zero irritation, safe for long-term use in sensitive skin and mild formulas.
• Stable Formula & Strong Synergy: Excellent formula stability, not easy to oxidize and inactivate, highly compatible with antioxidants and brightening ingredients, multi-dimensional synergistic anti-aging and skin beautifying effects.
Applications
• Anti-Glycation Brightening Skin Care Series: Core functional raw materials for anti-sugar essence, yellowing removal lotion and brightening cream, specially improving sugar-aged dull and yellow skin.
• Skin Barrier Repair Products: Applied in sensitive skin soothing lotion, barrier repair cream and postoperative mild maintenance products to repair damaged skin and stabilize skin health.
• Anti-Aging Firming Functional Formulas: Added in anti-aging firming essence, wrinkle smoothing cream and anti-relaxation skin care products to delay glycation aging and improve skin elasticity.
• High Moisturizing Daily Skin Care: Suitable for high-efficiency moisturizing milk, facial mask and dry skin care products to relieve dryness and lock water for a long time.
• High-End Mild Cosmetics: Used in high-end comprehensive anti-aging compound formulas, perfect for sugar-oxygen aging improvement and daily skin delicate maintenance.
Certificate Of Analysis (COA)
Test Item | Standard Specification | Test Result |
Product Name | D-Serine | Compliant |
CAS No. | 312-84-5 | Compliant |
Appearance | White Crystalline Powder, Odorless | Compliant |
Purity | ≥99.0% | 99.75% |
Specific Rotation | -14.0° ~ -16.0° | -15.2° |
Loss on Drying | ≤0.2% | 0.05% |
Residue on Ignition | ≤0.1% | 0.02% |
Heavy Metal (Pb) | ≤10ppm | Qualified |
Arsenic (As) | ≤2ppm | Qualified |
pH Value (1% Solution) | 5.5 - 7.0 | 6.0 |
Conclusion | Conforms to cosmetic grade quality standard | Qualified |
Frequently Asked Questions (FAQ)
• Q1: What is the MOQ of cosmetic grade D-Serine? A1: The standard MOQ is 1KG, and sample orders are supported for quality testing.
• Q2: What certification documents can be provided? A2: Complete COA, MSDS and full set of global customs clearance documents are available.
• Q3: What is the recommended dosage in cosmetic formulas? A3: Conventional addition ratio is 0.3%-2.5%, with stable anti-glycation, moisturizing and repairing effects, mild and non-burden on skin.
• Q4: What is the core difference between D-Serine and L-Serine? A4: D-Serine has prominent targeted anti-glycation activity, focusing on improving sugar aging and yellowish dull skin, while L-Serine focuses more on basic moisturizing and keratin synthesis; the two can be compounded for comprehensive anti-aging effects.
• Q5: Is D-Serine suitable for sensitive skin formulas? A5: Yes, it is ultra-mild low-sensitivity amino acid, stable and non-irritating, perfectly suitable for sensitive skin barrier repair and daily anti-aging maintenance.
• Q6: Do you support stable large-batch supply all year round? A6: Sufficient factory capacity ensures continuous and stable bulk supply throughout the year.
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